Have you read Deadpool kills the Marvel Universe comics? Well, a little summary:
Logan and some other guys bring Wade to a kind of asylum without his consent because they think Wade has gone to far with his crazyness and he needs it. There, bad guy inserts some kind of virus in Wade's head and manipulates him telling him that he has to kill all the superheroes, Wade does it without knowing because when he is killing someone he hallucinates about that someone and him having a great time like good friends and doing funny things. Its not until he kills everyone that he realizes what he has done, he goes for revenge on the guys that did that to him, but what's done is done.
So I thought that somehow the Wade from that universe teleports to the post-movie Deadpool and Wolverine. He meets them but always as a hostile way, because he's too traumatised, like, I killed my friends a long time ago but now theyre here and I'm supposed to not have PTSD???
I like this idea because this is similar to Worst Wolverine lore and I think Logan at some point could make him see reason and finally give him a hug and tell him it was gonna be ok.