Not part of the story
So the only thing that I'm already having apply in the story is that nature combination Kekkei Genkai/Tota such as, Lava Release, Magnet Release, and Wood Release aren't fully limited to the people of specific families but are just techniques that can be taught to anyone who has mastery over the elements that they are composed of, and some of them are just common in some families like how all Uchiha naturaly have fire style. What this means most immediatly is that many if not all Senju clan characters you see in this story will have wood style to some degree and Hashirama was just very talented. Now some things I'm just kinda thinking about are; Having the Rinnegan not just be yet another version of the Sharringan, but a dojutsu belonging to the Uzumaki clan. With its connection to the concept of rebirth, their clan's invention of sealing jutsu that summons the literal god of death for their world, and them also being descendants of the Ōtsutsuki clan like the other two/three clans with the Three Great Eyes I think it could work, plus it would explain why it took basically all of the nations, except for the land of fire, outside of them "having an affinity for sealing jutsu". Then I'm thinking about having it be where there are different versions of certain nature transformation combinations. Like how Earth Release with Water Release makes Wood Release, but it also makes Mud Release, and there also seems to be two different types of Magnet Release the kind that Gaara and the other Kazekage have with their sand/dust but also Toroi from the Hidden Cloud who has a more standard type of magnetism. Well that's all I'm thinking of at the moment, again I'd love to hear your opinions on these things in the comments, the next chapter will cover Shirubā getting some help training after his match with Minato.